Companion FOR GEORGIA’S VETERINARY COMMUNITY FROM BLUEPEARL VETERINARY PARTNERS FALL 2015 What’s New in Dermatology? Chemotherapy Safety is our Responsibility GONE ARE THE DAYS of mitaban dips, doramectin DOG BITES AND CAT SCRATCHES are an everyday risk in our field. We work hard to train our staff how to restrain injections and daily oral ivermectin for months on end. Two new weapons have emerged in the evolving war on demodicosis: Merial’s Nexgard® (afoxolaner), and Merck’s Bravecto® (fluralaner). Veterinary dermatologists have been discussing treatment successes they are seeing following once-monthly administration of Nexgard, or once every 2-3 months of Bravecto. Currently, as with doramectin and ivermectin, treatment of demodicosis with these drugs is extra label; thus, pet owners should be informed of this prior to prescription. The serious adverse reactions reported with ivermectin and/or doramectin (i.e. blindness, ataxia, possible death in MDR1 genedeficient dogs) were not reported in well-controlled field/laboratory studies. Common side effects observed include GI upset (vomiting, inappetence, diarrhea, flatulence), polydipsia and/or lethargy. Monitoring of treatment progress with every 4-6 weeks skin scrapings is still recommended, and continuation of treatment until achieving two negative scrapings 4 weeks apart remains the standard of care. As we know, Apoquel® (oclacitinib) has been popular during the last two years. While Zoetis is challenged to keep up with demand for this ‘miracle’ drug, veterinary dermatologists have had a fairly steady supply of the drug and are currently reporting fair to excellent control of atopic symptoms in approximately 65% of patients. When prescribing Apoquel, it’s important to understand that this drug is not without limitations and/or adverse effects, including labeled for use in dogs one year and older, increased incidence of papillomatous growths, development of urinary tract infections, weight gain, elevations in liver enzymes, blood dyscrasias, and rarely, acute death. Furthermore, it is important to perform a full medical work-up to rule out other possible causes for pruritus, such as bacterial pyoderma secondary to demodicosis, cutaneous lymphoma, or other non-allergic pruritic dermatoses, as failure to do so can result in further progression of the disease. Clinical improvement of allergic otitis is lacking. Apoquel may be an excellent secondary drug for managing symptoms of atopy in the initial stages of immunotherapy; however, it should not be seen as a replacement. b lu ep ea rlve t.co m our patients in order to minimize this danger. But are all of us paying as much attention as we should to less obvious dangers, such as handling of cancer drugs? Chemotherapy administration has been linked to infertility, abortion, miscarriage, leukemia and other forms of cancer in human studies. More immediate side effects such as headaches, skin irritation and intestinal upset have also been associated with the handling of anti-cancer agents. Strict rules and government regulations exist in many industries for managing hazardous materials. If these rules are broken, OSHA can take action against the employer. Most of us would consider chemotherapeutic agents to be hazardous materials. However, there is limited government oversight of chemotherapeutic agents in both the human and veterinary medical fields. What does exist are voluntary guidelines created in 1986 by the National Institute for Occupational Safety and Health (NIOSH). It is up to us to educate ourselves and our staff about the risks and safety steps, which should be taken when administering cancer agents. Wearing gowns and gloves is strongly recommended to prevent direct contact of the drug with skin and clothing if any drips or spills occur. Face protection with goggles or shields is also recommended in case there is splashing or spraying of the drugs. One of the biggest means of human exposure is aerosolization of the cancer agent when drawing up the chemotherapy drugs and during their administration. To reduce exposure while drawing up the drug a biological safety hood is recommended. Closed administration systems are available that lock the syringes to the drug Proper handling of chemotherapy medications is just as important to our safety as proper restraint techniques. Both are displayed here. vials to further minimize the chance for aerosolization or spillage. Many chemotherapy drugs come as tablets or capsules. It is important to not crush, split, or break open these tablets or capsules as this also causes aerosolization. Furthermore, not all drugs are evenly distributed within the tablet or capsule. Halving the tablet does not mean the patient is receiving half the dose. Compounding pharmacies are good resources if specialsized tablets are needed. Make sure the compounding pharmacy uses sterile procedures and pharmaceutical grade components. Owners giving oral chemotherapy at home should wear gloves when administering the tablets and capsules; be educated on the risks to their health; and be instructed on how to dispose of urine and feces. Many injectable chemotherapy drugs are vesicants, i.e. they cause damage to the tissues outside the vein. It is important to know the side effects and risks of the drugs you are using. Intravenous drugs should be given through a catheter. A butterfly catheter may not be adequate for many vesicant drugs as it can easily pierce through the vein. After giving chemotherapy, left over items such as gloves and syringes should be disposed of properly in specially marked waste containers. Check with your medical waste disposal company to determine how they want the chemotherapy supplies disposed of. At BluePearl Veterinary Partners, our clinicians and technicians continually strive to educate pet owners about these medications. The NIOSH website for more information is www.cdc.gov/niosh/docs/2004-165/. MANY CHEMOTHERAPY DRUGS COME AS TABLETS OR CAPSULES. IT IS IMPORTANT TO NOT CRUSH, SPLIT, OR BREAK OPEN THESE TABLETS OR CAPSULES AS THIS ALSO CAUSES AEROSOLIZATION. Sandy Springs 455 Abernathy Road NE Atlanta Georgia 30328 404.459.0903 Gwinnett 1956 Lawrenceville-Suwanee Road Lawrenceville Georgia 30043 770.277.8600 Healthcare-Associated Infections: Don’t Be the Cause of the Problem SNIFF… Meet our specialist… Kevin Winkler, DVM, DACVS Surgery Service HEALTHCARE-ASSOCIATED INFECTIONS (HAI), also called nosocomial infections, are those that Kevin Winkler, DVM, DACVS, is a home-grown Georgia boy who readily admits he’s an adrenaline junkie, stubborn, a bit geeky, sometimes a little full of himself, but always honest. He loves to share his knowledge, which includes instructing K-9 officers in emergency first aid or teaching veterinary interns and residents. Prior to joining the Georgia team, Dr. Winkler spent more than 10 years in surgery and emergency critical care for referral hospitals in North Carolina and Wisconsin. He graduated from the University of Georgia College of Veterinary Medicine and completed an internship and residency at the University of Illinois-Urbana. In his spare time he enjoys spending time with his wife, children and granddaughter. Get to know Dr. Winkler. What was your first job? Making burgers at Hardees. They still make the best biscuits! How do you like to work with the primary care veterinarian? I see my role as support to the primary care veterinarian. I like to share knowledge and help the primary care veterinarian with the surgical management of a case, whether that is through simple advice over the phone, or direct care of their patient for a specific problem. develop in patients during hospitalization. Most HAIs in humans are introduced during surgical procedures or develop secondary to the presence of invasive devices such as intravenous and urinary catheters. The most common cause of HAIs is microbes residing on or in the patient themselves. Studies have also demonstrated that microbes residing on the hands of healthcare workers and those present on surfaces of furnishings, equipment and instruments can serve as sources of HAIs. In 2002, approximately 1.7 million human HAIs resulted in close to 100,000 deaths. The prevalence of HAIs in the veterinary field and their effect on the health of canine and feline patients has not been extensively studied. Similar to humans, HAIs have been described in dogs secondary to surgical procedures and associated with urinary catheters. In one study 83% of veterinary teaching hospitals reported HAIs in their patients during a fiveyear period. Fifty percent of these hospitals reported at least one incident of a zoonotic HAI developing in a staff member. HAIs should be of concern to us in the veterinary field. They can increase and/or prolong hospital stays, add to the patient’s expense, and increase patient discomfort and morbidity. They may contribute to the death of our patients both directly from the infection and indirectly when owners decide they can’t afford the additional expense required to treat a new or complicating problem. HAIs gain entrance to a patient’s body via contamination of open wounds, or they can be inhaled/ingested, be introduced with instrumentation, or enter along medical devices such as catheters. It is cheaper and much safer to prevent invasion of the body by What’s your definition? microbes than to try to kill them after infection has set in. What can we do to Disinfectant: an agent that reduces minimize HAIs? 1. Disinfect the hospital environment frequently. Microbes on surfaces (faucet handles, cage doors, tub sinks) can directly contaminate our patients who come in contact with these surfaces or be transmitted indirectly when we handle these items and then the patient. What keeps you interested in cases day-to-day? There is always something new. However, you have to use your brain because that new toy/drug/procedure isn’t necessarily always better. Was there a college professor that changed your life? Dr. Aron, at UGA, had a nickname for everyone. Liked by some and not so much by others, Dr. Aron was always up front with you. What I remember most was his intolerance for blaming a failed outcome on client compliance. There was always something else the surgeon should have done to anticipate and avoid any client-created complications. He didn’t tolerate excuses such as, “the owner must not have restricted the pet.” The onus was on you, the DVM, to find a technique that would result in a successful outcome. Because of this, I will always be my toughest critic and have a hard time accepting a failed outcome. Even in a no-win scenario, I always feel there is something we could have done differently to allow success. What is something people might be surprised to know about you? I have a fear of heights, so I went skydiving. I’ve also always wanted to go into space, so I tried the next closest thing, SCUBA. If you knew then what you know now, what would you do differently? Spend more time with my kids when they were young and less time at work. Medical Director : Mark Dorfman, MS, DVM, DACVIM Hospital Administrator: Barbara Schick, RVT CARDIOLOGY Danielle Laughlin DVM, DACVIM Brandon Pogue DVM, DACVIM CRITICAL CARE Chris Piscitelli DVM, DACVECC Jennifer Pittman DVM, DACVECC Tom Walker DVM, DACVECC Antiseptic: an agent that reduces the quantity of potential microbial pathogens on living objects such as the skin of our patients and ourselves Sterilization: the complete elimination of all forms of microbial life 2. Reduce ourselves as a source of transfer of microbes. a. Wear and then dispose of gloves when cleaning contaminated environmental surfaces. b. Wash our hands with an antiseptic/soap combination after each patient. c. Wear gloves when handling compromises to the skin or membranes including open wounds and surgical incisions, as well as catheters. 3. Reduce the quantity of potential pathogens on the patient through the appropriate use of antiseptics and antiseptic scrubs. 4. Attempt to maintain barriers to infection in our patients by practicing good surgical technique; appropriate wound care, such as keeping wounds and drains covered with sterile bandages; and the judicious placement and care of catheters and their removal when no longer needed. Outside of veterinary medicine, what do you consider yourself to be an expert at? Having an opinion. If you didn’t choose veterinary medicine, what do you think you’d be doing today? I wanted to fly for the Navy. the quantity of potential microbial pathogens on inanimate objects such as table surfaces, faucet handles, floors Frequent hand washing is one of the easiest ways to minimize the transmission of infection among patients. 5. Utilize sterile equipment and instruments. Is sterility always necessary? Potential microbial pathogens, i.e. bacteria, viruses, fungi and protozoa, vary in their ability to subsist in the environment and in their ability to be transmitted and develop within potential hosts. The goal of disinfectant and antiseptic use is not necessarily to eradicate all potential pathogens but to reduce their numbers below that which might be necessary to induce an HAI. Barriers to infection, i.e. the skin and mucus membranes as well as the local Gloves should be worn and systemic immune system, will also protect the patient. Those whenever handling open patients with compromised barriers to infection secondary to skin wounds. breaks or immunosuppression from illness are at greater risk for developing an HAI. DERMATOLOGY Robert Schick DVM, DACVD DIAGNOSTIC IMAGING Mason Savage DVM Gustavo Sepulveda DVM, DACVR EMERGENCY MEDICINE Amanda Cobb DVM DaShaunté Coleman DVM Katherine Conlon DVM Stanley Hunter DVM Keith Mihansky DVM Kevin Nix DVM Sayra Reyes DVM Jean Sonnenfield DVM INTERNAL MEDICINE Nick Berryessa DVM, DACVIM Alysa Cook DVM, DACVIM Michael Di Cicco DVM, DACVIM Mark Dorfman DVM, DACVIM Derek Duval VMD, DACVIM Lisa Langs DVM, DACVIM Meri Miller DVM, DACVIM NEUROLOGY/NEUROSURGERY Ronald Johnson DVM, DACVIM Jennifer Parkes DVM, DACVIM Vaccines or Titers? IT’S NO SURPRISE THAT THE ANTI-VACCINATION trend in human medicine has carried over into veterinary medicine. We’re sharing this article, written by our colleague in Illinois, Susan Yohn, DVM, MS, DABVP Canine/Feline, DACVIM, to provide you with more information. Vaccine products have been used in companion animal medicine for more than 40 years. They could arguably be considered one of the most important scientific advancements that have helped us improve quality and longevity of the life of our cat and dog patients. In the last decade, a significant change in our thinking about vaccination protocols has been seen due to several different factors. Our understanding of the science of vaccination-induced immunity has evolved suggesting more prolonged infectious disease protection with specific core vaccines (canine distemper, parvovirus, adenovirus; feline panleukopenia virus). Major veterinary associations (AAHA and AVMA) with the support of vaccine manufacturers now recommend reassessment of annual vaccination protocols, especially for the core vaccines. Vaccination every three years has become accepted practice by many veterinary practices. Vaccine manufacturers have introduced new products with more extended duration of immunity and fewer antigenic components. Our society has become more concerned about possible vaccine reactions in children, and this has also created concern over side effects in pets. Side effects are fortunately infrequent in dogs and cats, but there has been association between vaccination and the development of vaccine sarcomas in cats and immune-mediated disease in dogs. With the concern from pet owners about “over vaccination” and the possibility of serious vaccine side effects, clients may now be requesting vaccine titers instead of vaccines. How reliable are these vaccine titers? Vaccine titers have been the cornerstone of the change in our knowledge about vaccine protection. They measure the presence of serum antibody able to neutralize the virus and prevent infection. IgG is the antibody class measured by vaccine titer assays. Studies have shown that for specific viral diseases in dogs (parvovirus, distemper, adenovirus) and cats (panleukopenia virus) protection after initial appropriate vaccination can last for 4 to 10 years based on serologic titer results and challenge studies. The “gold standard” assays for these virus titers are the viral neutralizing titer (VIN) and hemagglutination inhibition (HI). Most state diagnostic labs utilize the gold standard methodologies. Most, if not all, commercial veterinary laboratories have qualified and standardized alternative methodologies including enzyme immunoassays (ELISA) and immunofluorescence assays (IFA) to provide similar titer information compared to the gold standard VIN and HI assays. Due to variations in lab assay methodologies, different reference ranges, and potential change in titers from the pet over time, titers should not be compared between different laboratories. In-clinic titer test kits for canine distemper, parvovirus, and adenovirus and feline panleukopenia virus are now available. TiterCHEK® (Zoetis) and VacciCheck® are the names of two commercially available in-clinic titer kits. Both test kit systems have been validated independently and correlated with the gold standard titer assays. Rabies virus titers can also be assayed by the fluorescent antibody virus neutralizing titer, but the assay is available only through a limited number of certified laboratories. How are these titers interpreted? Depending on the individual lab and test methodology used, vaccine titer results may be reported as “protective” or “positive” (high antibody titer), “not protective” or “negative” (low antibody titer), or “borderline.” Some assays will provide an actual titer level from the laboratory to use in interpretation. The in-clinic titer test kits provide either a protected or not-protected result (TiterCHEK®) or a semi-quantitative score for serum antibodies (VacciCheck®). Protective, positive or high titers indicate that there is a high antibody titer to that virus either from vaccination or previous natural exposure or disease. For pets with a not protective, negative or low titer, lack of virus protection is of concern and booster vaccinations are recommended. The best correlation between antibody and protective immunity are for the viruses previously discussed (canine parvovirus, distemper, adenovirus, feline panleukopenia, rabies). It is important to remember that other factors may affect titer interpretation and risk for the pet. The immune system is complex. Antibodies target the foreign invaders for destruction, but other immune system cells actually destroy the invader. An insufficiency in the cell-mediated immune system (immunosuppression) may leave a pet at risk for disease even if protective titers are present. Even if a titer is considered low, exposure to the same antigen may result in a rapid immune response with new antibodies produced within hours to days. These animals may be susceptible to infection but may be fully protected due to immune-cell memory and cell-mediated immunity. By law, rabies vaccine titers cannot be used in place of re-vaccination. When a rabies vaccination is not current, a pet that bites someone must be considered unvaccinated and quarantined. Antibody titers to vaccines other than the core viruses have limited or no value as “protective titers.” Antibodies may persist for a short time, and there is no correlation between serum antibody testing and protection. This includes antibody testing for leptospirosis, feline herpes virus, feline calici virus, Lyme disease, and Bordetella. With other diseases, feline immunodeficiency virus for example, titer levels equate only to exposure to the pathogen or active infection. What is the appropriate clinical application of these titers for the veterinary patient? Protective titer levels may be appropriate clinically for specific patients. The most common application of vaccine titers is to help determine the need for vaccination in an adult pet. The reason for the request for titer assessment is often because of previous history of suspected or severe vaccine reactions in the pet, concurrent medical illness or just the owner’s concern about the need for vaccination. Evaluation of vaccine titers may be helpful to determine the need for core vaccines in other clinical scenarios: • Evaluation of vaccine response in a young pet to help identify nonresponders that may not be able to produce a protective antibody response • Identification of possibly unprotected pets with recent exposure to a contagious viral disease • Determination of antibody level in pet with unknown vaccination status • Management of infection risks and infectious disease outbreaks in shelters Vaccine titers may be helpful in determining the need for specific vaccines in the individual pet, but it is important that the owner understand the factors other than titer results that may affect the decision to vaccinate. Each veterinarian must determine the appropriate vaccination schedule for a patient based on risk of exposure, age of the pet and current medical status of the pet. Vaccine titers should not be considered a substitute for an appropriate core vaccine protocol for most clinically healthy pets. The recent outbreak of measles in children exposed to the virus at a national amusement park was suspected to be correlated with a decline in vaccination for this virus. This is a warning to us all and a reminder of the importance of consistent vaccination for “herd health.” All puppies and kittens should complete the recommended core vaccination protocols recommended with the last vaccine being at or beyond 16 weeks of age. An evaluation of pathogen exposure risk, lifestyle, age of the pet and concurrent medical problems along with vaccine titer status are all factors that should affect the decision to vaccinate the individual adult pet. Gastrointestinal Ulcers in Fido? GASTROINTESTINAL (GI) ULCERATIONS are inflammatory lesions that extend into the deeper layers of the gastrointestinal tract, going beyond the mucosa. GI ulceration is the result of factors that alter, damage or overwhelm the normal defense and normal repair mechanisms of the GI mucosal barrier. There is no predilection for a particular age group or breed, and signs can be extremely variable from patient to patient. Some patients may have no clinical signs, while others may be in immediate need of intensive support and hospitalization, including blood transfusions. Causes There are many potential causes of GI ulceration ranging from drugs/medication to tumors. Some cases of ulceration are clear-cut. A prime example would be in a case of high dose aspirin administration in a dog with severe arthritis. Others, and perhaps the majority, are more difficult to determine. NUTRITION Susan Wynn DVM OPHTHALMOLOGY Stacy Andrew DVM, DACVO ONCOLOGY/RADIATION THERAPY Terrance Hamilton DVM, DACVIM Nathan Lee DVM, DACVR-RO Rebecca Regan DVM, DACVIM Some of the more common causes of GI ulceration in our pets include •• the ingestion of certain medication (nonsteroidal and steroidal anti-inflammatory drugs) •• metabolic disorders such as kidney failure, liver disease and hypoadrenocorticism (Addison’s disease) •• neoplasia/large tumors such as gastric carcinomas •• stress, pain, and/or major medical illness/surgery •• dietary indiscretion or the ingestion of foreign objects •• pancreatitis (inflammation of the pancreas) •• microscopic disease of the GI tract including inflammatory bowel disease or certain types of cancer (lymphosarcoma) •• toxins such as lead CONTINUED ON PAGE 4 SURGERY Alan Cross DVM, DACVS Julie Duval VMD, DACVS Lori MacDougall DVM, DACVS Cassandra Ruthrauff DVM, DACVS Kevin Winkler DVM, DACVS Associate Veterinarians Jyothi Algappen DVM Matthew Boothe DVM Kenneth Brand DVM Danielle DeBrincat DVM Emily Donaldson DVM Lauren Fout DVM Emily Harris DVM Kalyn Kitchings DVM Carolynne Kruckman DVM Leslie Shelnutt DVM Greysi Tavarez DVM Edward Trainor DVM Gastrointestinal Ulcers in Fido? CONTINUED FROM PAGE 3 Symptoms- What to Watch For There are a number of symptoms that patients with gastrointestinal ulceration may exhibit. The most common include any/all of the following: •• vomiting (with or without digested blood) •• melena •• decreased appetite •• weakness • hematemesis • abdominal pain • pale gums • collapse Diagnosis A presumptive diagnosis of GI ulceration can sometimes be made on the basis of history and clinical findings such as the previously mentioned aspirin administration or known foreign body ingestion. A full diagnostic work-up is recommend, regardless of the cause. A complete blood cell count (CBC), biochemical profile and urinalysis should be performed in all cases. A CBC will evaluate for the presence of infections, inflammation and anemia, sometimes associated with gastrointestinal ulceration. A biochemical profile evaluates organ function, which is important to establish if there may be an underlying metabolic disorder. Screening abdominal radiograph, although often within normal limits, may support the diagnosis of an ulcer secondary to a tumor or foreign body, although an ulcer cannot be seen. An abdominal ultrasound evaluates the abdominal organs and helps assess for the presence of tumors that may be associated with ulcers; however, ultrasound may not identify the GI ulcer itself. A contrast upper GI study with barium may identify ulcers. It is a safe test; however, is quite time consuming, and although helpful in some patients, results are not always conclusive. Gastrointestinal endoscopy is the gold standard in diagnosing GI issues. It may facilitate the removal of foreign bodies, evaluate for ulcers, and sample tissue for the presence of inflammation or cancer, which may cause the ulcer. It does require general anesthesia in our veterinary patients; however, it is a fairly quick and safe procedure. Other tests may be recommended on a case-by-case basis. These may include a liver function test for certain liver disorders, an ACTH stimulation test to rule out hypoadrenocorticism (Addison’s disease), and/or a blood lead level if lead exposure is a possibility. Treatment Management of gastrointestinal ulcers centers on treatment of the primary cause and blocking excessive stomach acid production. Rarely, in severe cases control of bleeding and blood transfusions may be indicated. Withholding all oral intake for a period of time allows the GI tract to rest and is an important part of treatment. Fasting allows the lining of the GI tract to heal. Gradual reintroduction of small amounts of bland food should then be instituted, gradually increasing the amount over several days. CONTINUED BELOW Companion 455 Abernathy Road NE Atlanta GA 30328 To go green and receive only an electronic version of the COMPANION, or to add your email to our address list, please send an email to [email protected]. Gastrointestinal Ulcers in Fido? Continuing Education CONTINUED FROM ABOVE Drugs that decrease acid production by the stomach expedite the resolution of GI ulcers. Examples include Pepcid® (famotidine), Cytotec® (misoprostol) and Prilosec® (omeprazole) to name a few. Gastrointestinal protectants and adsorbents sooth and coat an irritated GI lining and help bind harmful agents. A commonly used medication is Carafate® (sucralfate). Anti-emetic drugs and/or antibiotics are considered to treat some patients on a case-by-case basis. Pain medication should be considered in pets with ulcer disease. Ulcers can cause intense abdominal discomfort, and affected patients may benefit greatly. Endoscopy or surgery may be indicated to remove foreign objects or tumors causing ulcers, biopsy associated tissue with the ulcer, or remove an area of persistent hemorrhage (surgery). Fluid therapy may be necessary in some patients with severe GI ulceration to correct dehydration. Additionally, blood transfusions may be indicated in the severely anemic patients. BLUEPEARL IS STRONGLY COMMITTED to the veterinary community. One of the ways we demonstrate this commitment is through our continuing education program, which is subsidized in part by our Partners in Education. All BluePearl CE lectures are free and open to all area veterinary professionals. Registration is required, please. Programs begin with a light dinner prior to the presentation, which starts at 7:30PM. To RSVP, please email [email protected]. For the most current information about BluePearl CE, please click the For Veterinarians tab on our homepage: bluepearlvet.com/georgia. DATE TIME TOPIC & PRESENTER LOCATION Oct 20 Nov 17 CE HRS 7:30PM DVM CE: Hyperadrenocorticism Derek Duval, VMD, DACVIM Sandy Springs 2 hr 7:30PM DVM CE: Head Trauma Ronald Johnson, DVM, DACVIM-Neurology Thomas Walker, DVM, DACVECC Sandy Springs 2 hr BluePearl’s newsletters are produced for the veterinary community with support from Partners in Education: If you would like to receive an electronic version of Companion, please send an email to your Georgia Flood at [email protected]. Antech Diagnostics, Elanco, Hill’s Pet Nutrition, Stokes Pharmacy, Trupanion, Zoetis © 2015 BluePearl Veterinary Partners
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